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- Title
Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis.
- Authors
Coyle, N; Jones, I; Robertson, E; Lendon, C; Craddock, N
- Abstract
Up to half of parous females with bipolar disorder (manic depression) develop an episode of severe psychiatric disturbance, usually called puerperal psychosis, within a few days of giving birth. We report significant evidence (p<0.003) that variation at the serotonin transporter gene exerts a substantial (odds ratio=4) and important (population attributable fraction=69%) influence on susceptibility to such episodes.
- Publication
Lancet (London, England), 2000, Vol 356, Issue 9240, p1490
- ISSN
0140-6736
- Publication type
Research
- DOI
10.1016/S0140-6736(00)02877-4