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- Title
Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China.
- Authors
London, S J; Yuan, J M; Chung, F L; Gao, Y T; Coetzee, G A; Ross, R K; Yu, M C
- Abstract
Dietary isothiocyanates inhibit lung carcinogenesis in laboratory animals but human data are limited. Glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) conjugate isothiocyanates leading to more rapid elimination. Common deletion polymorphisms of GSTM1 and GSTT1 abolish enzyme activity. We hypothesised that chemopreventive effects of isothiocyanates might be heightened when enzymes that enhance their elimination are lacking.
- Publication
Lancet (London, England), 2000, Vol 356, Issue 9231, p724
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(00)02631-3