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- Title
Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease).
- Authors
McKoy, G; Protonotarios, N; Crosby, A; Tsatsopoulou, A; Anastasakis, A; Coonar, A; Norman, M; Baboonian, C; Jeffery, S; McKenna, W J
- Abstract
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an autosomal dominant heart muscle disorder that causes arrhythmia, heart failure, and sudden death. Previously we mapped the genetic locus for the triad of autosomal recessive ARVC, palmoplantar keratoderma, and woolly hair (Naxos disease) to chromosome 17q21, in which the gene for plakoglobin is encoded. This protein is a key component of desmosomes and adherens junctions, and is important for the tight adhesion of many cell types, including those in the heart and skin.
- Publication
Lancet (London, England), 2000, Vol 355, Issue 9221, p2119
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(00)02379-5