We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C.
- Authors
Lau, J Y; Mizokami, M; Ohno, T; Diamond, D A; Kniffen, J; Davis, G L
- Abstract
Serial serum samples and pretreatment and post-treatment liver tissue from patients with chronic hepatitis C virus (HCV) infection were tested for HCV RNA by reverse-transcription polymerase chain reaction and branched DNA signal amplification assays. At the end of treatment with interferon-alpha (IFN alpha), 4 of 5 patients showing no biochemical response (in alanine aminotransferase activity), 4 of 5 with transient responses, and 1 of 5 showing complete and sustained responses had HCV RNA detectable in serum. The corresponding numbers for liver tissue were 5, 5, and 0 (of 4). However, all 5 complete responders had virological relapses within 6 months. Biochemical response may not reflect virological profile during IFN alpha treatment of HCV.
- Publication
Lancet (London, England), 1993, Vol 342, Issue 8881, p1208
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(93)92187-x