We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases.
- Authors
Saunders, A M; Schmader, K; Breitner, J C; Benson, M D; Brown, W T; Goldfarb, L; Goldgaber, D; Manwaring, M G; Szymanski, M H; McCown, N
- Abstract
The frequency of the allele for apolipoprotein E type 4 (epsilon 4) is increased in late-onset familial and sporadic Alzheimer's disease (AD). We have examined epsilon 4 frequencies in four distinct, normal, elderly control groups and, most importantly, in patients with amyloid-forming diseases whose epsilon 4 distributions were not previously known (Creutzfeldt-Jakob disease, familial amyloidotic polyneuropathy, Down's syndrome). There were no differences between any of these controls and published control series, cementing the relevance of epsilon 4 for late-onset AD. The increase in late-onset AD was confirmed in two new series.
- Publication
Lancet (London, England), 1993, Vol 342, Issue 8873, p710
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(93)91709-u