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- Title
Acute toxicity of vitamin A given with vaccines in infancy.
- Authors
de Francisco, A; Chakraborty, J; Chowdhury, H R; Yunus, M; Baqui, A H; Siddique, A K; Sack, R B
- Abstract
A double-blind, randomised, placebo-controlled trial was conducted to evaluate the safety and toxicity of vitamin A supplementation within the Expanded Programme on Immunisation (EPI) in rural Bangladesh. 191 infants received 3 doses of either 50,000 IU of vitamin A or placebo at about 1.5, 2.5, and 3.5 months and were examined on days 1, 2, 3, and 8 after supplementation. 11 infants (11.5%) supplemented with vitamin A had episodes of bulging of the fontanelle as opposed to 1 (1%) in the placebo group. 16 of the 17 events occurred in the vitamin A supplemented group. No other side effects were noted. There was a tendency towards a cumulative effect of toxicity with increasing doses.
- Publication
Lancet (London, England), 1993, Vol 342, Issue 8870, p526
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(93)91648-6