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- Title
Intestinal permeability and the prediction of relapse in Crohn's disease.
- Authors
Wyatt, J; Vogelsang, H; Hübl, W; Waldhöer, T; Lochs, H
- Abstract
To see whether intestinal permeability (IP) predicted relapse in Crohn's disease, we measured IP in 72 patients with quiescent Crohn's disease using the lactulose-mannitol test. The permeability index (lactulose/mannitol) was significantly higher in patients than in controls (0.046 [SEM 0.005] vs 0.018 [SEM 0.002], respectively). Patients were followed for 1 year after the test. 26 of the 37 patients with raised permeability, but only 6 of the 35 with normal permeability relapsed within 1 year after the test (p < 0.001). The sensitivity of the permeability test as a predictor for relapse was 81%. A significant correlation was found between the value of the permeability index and the probability of relapse (p < 0.01). These results show that increases in intestinal permeability precede clinical relapses in Crohn's disease and so are an indicator of subclinical disease. The measurement of intestinal permeability may lead to a better understanding of the pathogenesis of Crohn's disease.
- Publication
Lancet (London, England), 1993, Vol 341, Issue 8858, p1437
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(93)90882-h