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- Title
Persistent hepatitis C viraemia without liver disease.
- Authors
Brillanti, S; Foli, M; Gaiani, S; Masci, C; Miglioli, M; Barbara, L
- Abstract
In viral infections persistence of the virus is not always associated with virus-induced disease. To find out if active hepatitis C virus (HCV) infection can persist without liver disease we selected four symptom-free individuals with antibodies to HCV but normal aminotransferase levels. They were followed up for 3 years by monthly serology and a liver biopsy was done. At presentation, all four had both antibodies to HCV and circulating HCV RNA. During follow-up their sera remained persistently positive for all HCV antibodies and RNA yet aminotransferase levels did not increase and liver biopsy was normal. These findings indicate that persistent hepatitis C viraemia is not invariably associated with liver damage.
- Publication
Lancet (London, England), 1993, Vol 341, Issue 8843, p464
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(93)90210-8