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- Title
Plasmapheresis for severe, unremitting, chronic urticaria.
- Authors
Grattan, C E; Francis, D M; Slater, N G; Barlow, R J; Greaves, M W
- Abstract
Histamine-releasing autoantibodies have been identified in chronic idiopathic urticaria. 8 patients with severe disease and histamine-releasing activity in their sera underwent plasmapheresis. Symptoms were abolished for 2 months in 1 patient and for 3 weeks in another, 2 showed almost complete resolution of symptoms, 2 had temporary relief, and the other 2 showed little change. Further investigation in 4 of the patients showed significantly reduced skin-test responses to fresh post-exchange autologous sera after plasmapheresis compared with stored pre-exchange sera, but the response to intradermal histamine remained unchanged. Blood cellular histamine increased as in-vitro serum histamine-releasing activity fell after plasmapheresis. These results favour a pathogenetic role for histamine-releasing autoantibodies in patients with chronic urticaria.
- Publication
Lancet (London, England), 1992, Vol 339, Issue 8801, p1078
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(92)90666-q