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- Title
Abnormal sulphur oxidation in systemic lupus erythematosus.
- Authors
Gordon, C; Bradley, H; Waring, R H; Emery, P
- Abstract
S-carboxy-L-methylcysteine was used to assess the activity of the S-oxidation pathway of sulphur metabolism in 35 patients with systemic lupus erythematosus (SLE); 25 (71%) showed impaired sulphoxidation and 21 (60%) produced virtually no sulphoxides, compared with 17 (36%) and 2 (4%), respectively, of 47 healthy controls. The substrate/product ratio of cysteine oxygenase (plasma cysteine/sulphate) was significantly higher in SLE patients than in controls (median [interquartile range] 362 [224-588] vs 65 [44-111]; p less than 0.00001). The alternative pathway of sulphur metabolism, S-methylation, catalysed by thiolmethyltransferase, was not impaired in the SLE patients. There is a biochemical difference in sulphur metabolism between SLE and rheumatoid arthritis, since both pathways are impaired in the latter disorder.
- Publication
Lancet (London, England), 1992, Vol 339, Issue 8784, p25
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(92)90144-r