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- Title
Production of interleukin-1-receptor antagonist during experimental endotoxaemia.
- Authors
Granowitz, E V; Santos, A A; Poutsiaka, D D; Cannon, J G; Wilmore, D W; Wolff, S M; Dinarello, C A
- Abstract
Interleukin-1 (IL-1) has been implicated in the pathogenesis of sepsis. IL-1-receptor antagonist (IL-1ra) is a naturally occurring inhibitor of IL-1 activity that competes with IL-1 for occupancy of cell-surface receptors but possesses no agonist activity. We induced endotoxaemia in 9 healthy human volunteers by injection of Escherichia coli endotoxin, and measured plasma concentrations of IL-1 and IL-1ra by radioimmunoassay during the next 24 h. Peak plasma concentrations of IL-1ra were about a hundred-fold greater than those of IL-1 beta. No IL-1 or IL-1ra were detectable in the plasma of 4 volunteers injected with saline. Our results suggest that the predominant natural response to endotoxin in man is the production of antagonist rather than agonist.
- Publication
Lancet (London, England), 1991, Vol 338, Issue 8780, p1423
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(91)92725-h