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- Title
First-pass metabolism of cyclosporin by the gut.
- Authors
Kolars, J C; Awni, W M; Merion, R M; Watkins, P B
- Abstract
Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood. Our findings indicate that the small intestine is a major site of cyclosporin breakdown: such intestinal metabolism might help to explain the poor oral bioavailability and drug interactions of cyclosporin.
- Publication
Lancet (London, England), 1991, Vol 338, Issue 8781, p1488
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(91)92302-i