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- Title
Central-nervous-system demyelination after immunisation with recombinant hepatitis B vaccine.
- Authors
Herroelen, L; de Keyser, J; Ebinger, G
- Abstract
2 patients had neurological symptoms and signs, with evidence of central-nervous-system demyelination, 6 weeks after administration of recombinant hepatitis B vaccine. 1 had known multiple sclerosis but the other had no history of neurological disease; both had HLA haplotypes DR2 and B7, which are associated with multiple sclerosis. A causal link between vaccination and demyelination cannot be established from these 2 case-reports, but the time interval would fit a proposed immunological mechanism.
- Publication
Lancet (London, England), 1991, Vol 338, Issue 8776, p1174
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(91)92034-y