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- Title
Interaction of citrus juices with felodipine and nifedipine.
- Authors
Bailey, D G; Spence, J D; Munoz, C; Arnold, J M
- Abstract
Six men with borderline hypertension took felodipine 5 mg with water, grapefruit juice, or orange juice. The mean felodipine bioavailability with grapefruit juice was 284 (range 164-469)% of that with water. The dehydrofelodipine/felodipine AUC ratio was lower, diastolic blood pressure lower, and heart rate higher with grapefruit juice than with water. Vasodilatation-related side-effects were more frequent. Orange juice had no such effects. Six healthy men took nifedipine 10 mg with water or grapefruit juice; the bioavailability with grapefruit juice was 134 (108-169)% of that with water.
- Publication
Lancet (London, England), 1991, Vol 337, Issue 8736, p268
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(91)90872-m