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- Title
Mortality in hereditary antithrombin-III deficiency--1830 to 1989.
- Authors
Rosendaal, F R; Heijboer, H; Briët, E; Büller, H R; Brandjes, D P; de Bruin, K; Hommes, D W; Vandenbroucke, J P
- Abstract
To determine whether antithrombin-III (AT-III) deficiency leads to an excess mortality, we studied 171 individuals from ten families with a proven hereditary deficiency. 73 were classified as certainly deficient either by direct measurement of AT-III concentration or by mendelian inheritance patterns. 98 individuals had a high probability (0.5) of deficiency. The 64 deaths recorded did not exceed those expected for the general population adjusted for age, sex, and calendar period. We suggest that a policy of prophylactic anticoagulation for patients with AT-III deficiency cannot be recommended.
- Publication
Lancet (London, England), 1991, Vol 337, Issue 8736, p260
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/0140-6736(91)90867-o