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- Title
The impact of isolated proximal limb heating on arterial wave reflection.
- Authors
Athaide, Chloe; Cohen, Jeremy; Stevens, Kailey; Robertson, Andrew; Jason Au
- Abstract
Background: Arterial wave reflection occurs in the peripheral circulation subsequent to each contraction of the left ventricle (1). Mathematical models and comparative physiology (2,3) suggest that the lower limbs are the primary source of reflected waves; however, in vivo human evidence corroborating these observations is lacking. This study was designed to determine whether the lower or upper limbs contribute more to the summated reflected wave. We hypothesized that heating of the lower limb will result in larger changes in central wave reflection compared to heating of the upper limb. Methods: Fifteen healthy adults (8 females, 24 ± 3.6 years) completed a within-subjects experimental crossover protocol with a washout period. The right arm and leg were warmed in a randomized order using 38 °C water-perfused tubing with a 30-min break between protocols. Wave reflection was estimated at baseline and after 30 min of heating from pressure-flow relationships derived from aortic blood flow and carotid blood pressure. Results: There was a main effect of time for reflected wave magnitude (12.8 ± 2.7 to 12.2 ± 2.6 mmHg) and augmentation index (- 7.49 ± 8.92 to - 4.45 ± 9.07%) (p = 0.029 and 0.034, respectively), but no significant differences for condition or interactions. Conclusion: Proximal limb heating reduced central wave reflection magnitude; however, the lack of a difference between conditions does not support the hypothesis that the lower limbs are the primary source of wave reflection. Further research is required to confirm the role of the limbs in generating central wave reflections, with recommendations for future studies to consider the role of the gastrointestinal vasculature.
- Publication
Artery Research, 2023, Vol 29, Issue 1, pS44
- ISSN
1872-9312
- Publication type
Academic Journal
- DOI
10.1007/s44200-022-00028-8