Your institution may have access to this item. Find your institution then sign in to continue.

Title: Multi-step continuous flow synthesis of fluconazole.
Authors: Szeto, Judy; Vu, Vi-Anh; Malerich, Jeremiah P.; Collins, Nathan
Abstract: The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system.ᅟ
Subjects: FLUCONAZOLE; ANTIFUNGAL agent synthesis; FLOW chemistry; ACETOPHENONE synthesis; CHEMICAL processes
Publication: Journal of Flow Chemistry, 2019, Vol 9, Issue 1, p35
ISSN: 2062-249X
Publication type: Academic Journal
DOI: 10.1007/s41981-018-0019-0

We found a match

Multi-step continuous flow synthesis of fluconazole.