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- Title
Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen.
- Authors
Abdel-Dayem, Marwa A; Elmarakby, Ahmed A; Abdel-Aziz, Azza A; Pye, Chelsey; Said, Shehta A; El-Mowafy, Abdalla M
- Abstract
The polyunsaturated, ω-3 fatty acid, docosahexaenoic acid (DHA), claims diverse cytoprotective potentials, although via largely undefined triggers. Thus, we currently first tested the ability of DHA to ameliorate valproate (VPA)-evoked hepatotoxicity, to modulate its anticonvulsant effects, then sought the cellular and molecular basis of such actions. Lastly, we also verified whether DHA may kinetically alter plasma levels/clearance rate of VPA.
- Publication
Drugs in R&D, 2014, Vol 14, Issue 2, p85
- ISSN
1179-6901
- Publication type
Journal Article
- DOI
10.1007/s40268-014-0042-z