We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacokinetics and toxicity of intrathecal liposomal cytarabine in children and adolescents following age-adapted dosing.
- Authors
Peyrl, Andreas; Sauermann, Robert; Chocholous, Monika; Azizi, Amedeo A; Jäger, Walter; Höferl, Martina; Slavc, Irene
- Abstract
Assessment of the optimal drug dose for intrathecal therapy in children is challenging because of the non-linear increase in cerebrospinal fluid (CSF) volume throughout childhood and potential differences in the elimination rate in children versus adults. The present study was designed to prospectively collect pharmacokinetic and safety data on age-adapted intrathecal liposomal cytarabine in children aged >3 years.
- Publication
Clinical pharmacokinetics, 2014, Vol 53, Issue 2, p165
- ISSN
1179-1926
- Publication type
Journal Article
- DOI
10.1007/s40262-013-0106-1