Title

Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora.

Authors

Nalin Rathnayake, G. R.; Savitri Kumar, N.; Jayasinghe, Lalith; Araya, Hiroshi; Fujimoto, Yoshinori

Abstract

An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition to previously identified pitholide B (2), pitholide D (3), pestalotin (LL-P880α) (4), PC-2 (5), LL-P880β (6), tyrosol (7) and 4-oxo-4H-pyran-3-acetic acid (8). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1–5, 7 and 8 from P. microspora are reported here for the first time.

Subjects

ENDOPHYTIC fungi; METABOLITES; MICROSPORIDIA; DEXTROSE; MYCELIUM

Publication

Natural Products & Bioprospecting, 2019, Vol 9, Issue 6, p411

ISSN

2192-2209

Publication type

Academic Journal

DOI

10.1007/s13659-019-00225-0