Title

The role of serum level of irisin in diabetic retinopathy.

Authors

Mazloum Khorasani, Zahra; Hosseini, Seyedeh Maryam; Safaei, Mohammadreza; Mehrad Majd, Hassan; Sarabi, Mehrdad; Torshizian, Ashkan; Nikpasand, Niloofar; Saeedi, Nikoo; AkbariRad, Mina

Abstract

Objective: Diabetes retinopathy (DR) is one of the top listed world health issues. Screening is usually advised for diabetic cases on a routine basis. However, there is only partial access to ophthalmologists in all parts of the world. Irisin is a myokine that is being investigated for this reason. Our study aims to assess the role of irisin in detecting DR. Methods and materials: In a cross-sectional study, 140 diabetes cases, including 70 patients with diabetic retinopathy and 70 patients free from diabetic retinopathy, were enrolled. Demographic and anthropometric data were gathered, and the patients underwent physical examination. Also, microalbuminuria and serum irisin levels were assessed in both groups. The results were compared between the two study groups. Results: Among the enrolled cases, 55 (39.28%) were men, and 85 (60.72%) were women. The disease duration (p = 0.016) and the serum level of HBA1c (p = 0.014) were significantly higher in the diabetic retinopathy group compared to the group free from diabetic retinopathy. Moreover, irisin was significantly higher in the patients free from diabetic retinopathy (p = 0.007). Conclusion: Irisin may have value in screening diabetic retinopathy; however, further studies are needed for this proposal.

Subjects

CROSS-sectional method; ALBUMINURIA; GLYCOSYLATED hemoglobin; DIABETIC retinopathy; DESCRIPTIVE statistics; SERUM; FIBRONECTINS; TYPE 2 diabetes; PATHOLOGICAL laboratories; MEDICAL screening; ANTHROPOMETRY; COMPARATIVE studies; MYOKINES; BLOOD

Publication

International Journal of Diabetes in Developing Countries, 2024, Vol 44, Issue 2, p350

ISSN

0973-3930

Publication type

Academic Journal

DOI

10.1007/s13410-023-01235-y