Works matching DE "TUMOR microenvironment"

Results: 5000

Integrating bulk and single-cell RNA sequencing reveals intratumor heterogeneity phenotypes and immune infiltration in pancreatic cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03080-3

By:

Zhao, Li;
Huang, Yao;
Li, Jiang;
Xie, Rui;
Li, Kaiming

Publication type:

Article

Genetic determinants of head and neck cancer: exploring causality among immune cells and plasma metabolites through two-sample Mendelian randomization and mediation analysis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03181-z

By:

Lu, Yuting;
Du, Xiangnan;
Liu, Hanlin;
He, Qing;
Cao, Xiaolin

Publication type:

Article

Mechanism of crosstalk between Helicobacter pylori and immune stromal cells in the development and occurrence of gastric cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03163-1

By:

Wu, Yang;
Zhang, Runbing;
Li, Tian;
Zhang, Jiucong;
Yu, Xiaohui;
Zheng, Xiaofeng

Publication type:

Article

SLC3A2 as a key anoikis−related gene for prognosis and tumor microenvironment remodeling in melanoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03125-7

By:

Liu, Xiaojin;
Xie, Jiaheng;
Xiao, Yingying

Publication type:

Article

SPDL1 overexpression was associated with poor prognosis and immune status in HCC through in vitro experiment and bioinformatics analysis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03089-8

By:

Xu, Ying-Ming;
You, Bo-Hua;
Chen, Ming;
Xiong, Tian-Ping;
Shi, Lin;
Wei, Qin;
Wang, Zhong-An

Publication type:

Article

Zwilch kinetochore protein affects the prognosis of cancer patients by participating in cell proliferation, enhancing cell communication, and reshaping the tumor microenvironment.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02981-7

By:

Yao, Long;
Liu, Lianpo;
Wu, Jinsong;
Huang, Yunlong;
Zhang, Renquan;
Zhang, Haoxue

Publication type:

Article

Hypoxia- and lactate metabolism-associated prognostic and therapeutic signature in pancreatic cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02873-w

By:

Zhang, Chen-Hui;
Huang, An-Qi;
Shi, Cang-Chang;
Jiang, Zhi-Jia;
Yao, Hao;
Sun, Jin-Jin

Publication type:

Article

Exploring the potential value of SRC in pan cancer based on bioinformatics methods.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02402-9

By:

Huang, Liyin;
Lu, Yanwen;
Yi, Lei;
Zhao, Yuxin;
Si, Tao;
Zhang, Mingmin

Publication type:

Article

Deep learning-based tumor segmentation and radiogenomic model for predicting EGFR amplification and assessing intratumoural heterogeneity in glioblastoma.

Published in:

Journal of Big Data, 2025, v. 12, n. 1, p. 1, doi. 10.1186/s40537-025-01221-7

By:

Liu, Jianpeng;
Shen, Chuyun;
Jiang, Shufan;
Wu, Yanfei;
Tu, Jiaqi;
Bao, Yifang;
Li, Haiqing;
Wang, Na;
Liu, Ying;
Xiong, Ji;
Liu, Xueling;
Li, Yuxin

Publication type:

Article

T cells in cancer: mechanistic insights and therapeutic advances.

Published in:

Biomarker Research, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40364-025-00807-w

By:

Pu, Jingjing;
Liu, Ting;
Zhou, Yi;
Chen, Mengping;
Fu, Xuehang;
Wan, Yike;
Wang, Junying;
Chen, Binzhen;
Sharma, Amit;
Lukacs-Kornek, Veronika;
Schmidt-Wolf, Ingo G.H.;
Hou, Jian

Publication type:

Article

TMEM150A overexpression was associated with poor prognosis and cancer progression in glioma verified by comprehensive analysis and cell experiments.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-08752-2

By:

Xu, Hao-Qiang;
Zhao, Dan;
Xu, Shi-Hao;
Mao, Rui;
Yang, Wen-Qiong;
Han, Qi

Publication type:

Article

Comprehensive analysis of Mendelian randomization and scRNA-seq identify key prognostic genes and relevant functional roles in colorectal cancer.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10354-x

By:

Hu, Meng;
Dong, Haotian;
Chen, Chujia;
Ye, Chengyuan;
Yan, Jianing;
Yu, Xuan;
Ye, Guoliang;
Shao, Yongfu

Publication type:

Article

Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcoma.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10290-w

By:

Cao, Qianqian;
Zhang, Yuzhe;
Cheng, Cheng;
Wang, Xiaoyang;
Fan, Panlong;
Huang, Jincheng;
Dai, Zhipeng

Publication type:

Article

Characterization of lysine crotonylation-related lncRNAs for prognostic assessment and immune response in glioma.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1573694

By:

Song, Miaomiao;
Xu, Juan;
Gui, Zhonghao;
Wu, Yun;
Wang, Feifei;
Sheng, Hongmei;
Huang, Xueyong;
Qian, Junyu;
Qin, Haotian;
Wang, Ying

Publication type:

Article

Editorial: Mitochondrial damage interacts with the immune system and tumor microenvironment.

Published in:

2025

By:

Lin, Xundong;
Yuan, Xin;
Luo, Yiheng;
Fang, Haihong;
Guo, Weihong

Publication type:

Editorial

Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis and its therapeutic implications for targeted treatment strategies.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02623-5

By:

Pang, Boran;
Wu, Hao

Publication type:

Article

Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview.

Published in:

Molecules, 2025, v. 30, n. 13, p. 2792, doi. 10.3390/molecules30132792

By:

Wang, Wang;
Zhou, Hanting;
Sen, Akanksha;
Zhang, Pengxia;
Yuan, Linhong;
Zhou, Shaobo

Publication type:

Article

Integrative Multi-Omics Analysis Reveals the Molecular Characteristics, Tumor Microenvironment, and Clinical Significance of Ubiquitination Mechanisms in Lung Adenocarcinoma.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6501, doi. 10.3390/ijms26136501

By:

Long, Deyu;
Xue, Yajing;
Yu, Xiushi;
Qin, Xue;
Chen, Jiaxin;
Luo, Jia;
Ma, Ketao;
Wei, Lili;
Li, Xinzhi

Publication type:

Article

Effects of the Alkylating Agent Cyclophosphamide in Potentiating Anti-Tumor Immunity.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6440, doi. 10.3390/ijms26136440

By:

Gephart, Benjamin D.;
Coulter, Don W.;
Solheim, Joyce C.

Publication type:

Article

Biomimetic Tumour Model Systems for Pancreatic Ductal Adenocarcinoma in Relation to Photodynamic Therapy.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6388, doi. 10.3390/ijms26136388

By:

Smith, Olivia M.;
Lintern, Nicole;
Tian, Jiahao;
Mesquita, Bárbara M.;
Oliveira, Sabrina;
Vymetalkova, Veronika;
Prakash, Jai;
Smith, Andrew M.;
Jayne, David G.;
Heger, Michal;
Khaled, Yazan S.

Publication type:

Article

Shifting Shapes: The Endothelial-to-Mesenchymal Transition as a Driver for Cancer Progression.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6353, doi. 10.3390/ijms26136353

By:

Giordanengo, Lucia;
Proment, Alessia;
Botta, Virginia;
Picca, Francesca;
Munir, H. M. Waqas;
Tao, Jiahao;
Olivero, Martina;
Taulli, Riccardo;
Bersani, Francesca;
Sangiolo, Dario;
Novello, Silvia;
Scagliotti, Giorgio Vittorio;
Merlini, Alessandra;
Doronzo, Gabriella

Publication type:

Article

Unraveling the Role of Tumor-Infiltrating Immune Cells in Head and Neck Squamous Cell Carcinoma: Implications for Antitumor Immune Responses and Immunotherapy.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6337, doi. 10.3390/ijms26136337

By:

Arriola Benítez, Paula Constanza;
Fusco, Mariel;
Amorin, Ricardo;
Picón, Carlos Rafael;
Piccioni, Flavia;
Victoria, Lucia;
Rizzo, Manglio Miguel;
Malvicini, Mariana

Publication type:

Article

Rendering NK Cells Antigen-Specific for the Therapy of Solid Tumours.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6290, doi. 10.3390/ijms26136290

By:

Doeppner, Carina A.;
Binder, Amanda Katharina;
Bremm, Franziska;
Feuchter, Niklas;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

Silibinin Anticancer Effects Through the Modulation of the Tumor Immune Microenvironment in Triple-Negative Breast Cancer.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6265, doi. 10.3390/ijms26136265

By:

Mishra, Shubham D.;
Mendonca, Patricia;
Kaur, Sukhmandeep;
Soliman, Karam F. A.

Publication type:

Article

Caffeine as a Modulator in Oncology: Mechanisms of Action and Potential for Adjuvant Therapy.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6252, doi. 10.3390/ijms26136252

By:

Rembiałkowska, Nina;
Demiy, Alina;
Dąbrowska, Alicja;
Mastalerz, Jakub;
Szlasa, Wojciech

Publication type:

Article

Expression of WNT Family Genes in Mesenchymal Stromal Cells of the Hematopoietic Niche in Patients with Different Responses to Multiple Myeloma Treatment.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6236, doi. 10.3390/ijms26136236

By:

Belik, Liubov A.;
Enukashvily, Natella I.;
Semenova, Natalia Y.;
Ostromyshenskii, Dmitrii I.;
Motyko, Ekaterina V.;
Kirienko, Anna N.;
Kustova, Daria V.;
Bessmeltsev, Stanislav S.;
Sidorkevich, Sergey V.;
Martynkevich, Irina S.

Publication type:

Article

Modeling the Bone Marrow Niche in Multiple Myeloma: From 2D Cultures to 3D Systems.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6229, doi. 10.3390/ijms26136229

By:

Bottaro, Adele;
Nasso, Maria Elisa;
Stagno, Fabio;
Fazio, Manlio;
Allegra, Alessandro

Publication type:

Article

In Vitro Analysis of PMEPA1 Upregulation in Mesenchymal Stem Cells Induced by Prostate Cancer Cells.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6223, doi. 10.3390/ijms26136223

By:

Rakhmatullina, Aigul R.;
Zolotykh, Mariya A.;
Filina, Yuliya V.;
Sagdeeva, Aisylu R.;
Rozhina, Elvira V.;
Gabdoulkhakova, Aida G.;
Boulygina, Eugenia A.;
Miftakhova, Regina R.

Publication type:

Article

Exploring the Role of Peripheral Macrophages in Glioma Progression: The Metabolic Significance of Cyclooxygenase-2 (COX-2).

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6198, doi. 10.3390/ijms26136198

By:

Pietzsch, Jens;
Toussaint, Magali;
Donat, Cornelius Kurt;
Doctor, Alina;
Meister, Sebastian;
Wodtke, Johanna;
Laube, Markus;
Hofheinz, Frank;
Rix, Jan;
Deuther-Conrad, Winnie;
Haase-Kohn, Cathleen

Publication type:

Article

Immuno-Oncology at the Crossroads: Confronting Challenges in the Quest for Effective Cancer Therapies.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6177, doi. 10.3390/ijms26136177

By:

Roznovan, Claudiu Natanael;
Măruțescu, Luminița Gabriela;
Gradisteanu Pircalabioru, Gratiela

Publication type:

Article

Disparate Roles of Cell–Cell Contact and Cytokine Secretion in an In Vitro Model of the Seminoma Microenvironment.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6173, doi. 10.3390/ijms26136173

By:

Fruth, Patrick;
Luft, Juliane;
Klaus, Lucas;
Legler, Tobias J.;
Reichardt, Holger M.;
Gayer, Fabian A.

Publication type:

Article

Subtherapeutic Dose of Ionizing Radiation Reprograms the Pre-Metastatic Lung Niche, Accelerating Its Formation and Promoting Metastasis.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6145, doi. 10.3390/ijms26136145

By:

Oliveira, Paula de;
Vala, Inês Sofia;
Faísca, Pedro;
Guimaraes, Joao C;
Pina, Filomena;
Poli, Esmeralda;
Diegues, Isabel;
Osório, Hugo;
Matthiesen, Rune;
Serre, Karine;
Constantino Rosa Santos, Susana

Publication type:

Article

The Role of Fibroblasts in Melanoma Development: From Tumor Microenvironment Remodeling to Pre-Metastatic Niche Formation.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6132, doi. 10.3390/ijms26136132

By:

Belviso, Immacolata;
Pastore, Raffaele;
Mileo, Aldo;
Del Genio, Emiliano;
Boccia, Stefania;
Palermi, Stefano;
Sellitto, Carmine;
Motti, Maria Letizia

Publication type:

Article

Establishment of U-87MG Cellular Fibrosis as a Novel in Vitro Model to Analyze Glioblastoma Cells' Sensitivity to Temozolomide.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6121, doi. 10.3390/ijms26136121

By:

Lopardo, Valentina;
Esposito, Roberta Maria;
Pagano Zottola, Antonio C.;
Santoro, Federica;
Grasso, Nicola;
Carotenuto, Alfonso;
Puca, Annibale Alessandro;
Ciaglia, Elena

Publication type:

Article

PD-L1 Expression in NSCLC: Clouds in a Bright Sky.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6066, doi. 10.3390/ijms26136066

By:

Ferrari, Victoria;
Gal, Jocelyn;
Mograbi, Baharia;
Milano, Gerard

Publication type:

Article

Upregulated BAP31 Links to Poor Prognosis and Tumor Immune Microenvironment in Breast Cancer.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 5975, doi. 10.3390/ijms26135975

By:

Hao, Zhenzhen;
Zhao, Bo;
Zhu, Xiaoshuang;
Zhang, Wanting;
Wang, Bing

Publication type:

Article

Tumor-Associated Macrophage in Breast Tumor Microenvironment.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 5973, doi. 10.3390/ijms26135973

By:

Ma, Lingyao;
Jin, Yuexinzi;
Xu, Jian;
Zhang, Jiexin

Publication type:

Article

Identification of hub six interferon alpha response genes and immune cell infiltration characteristics in low-grade glioma.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-09646-z

By:

Zhang, Xue;
Song, Shuo;
Zhou, Defen;
Cui, Hanwei;
Xie, Jiangan

Publication type:

Article

Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-09535-5

By:

Ho, Gregory W.;
Santos, Alicia;
Fields, Jennifer;
Rosato, Pamela C.;
Turk, Mary Jo;
Steinmetz, Nicole F.;
Fiering, Steven

Publication type:

Article

Clinical and molecular characterizations of HNSCC patients with occult lymph node metastasis.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10320-7

By:

Li, Yicun;
Wu, Yun;
Li, Xiaolian;
Lin, Yuntao;
Chen, Yuling;
Yang, Hongyu;
Shen, Yuehong

Publication type:

Article

Development of Immune-Regulatory Pseudo-Protein-Coated Iron Oxide Nanoparticles for Enhanced Treatment of Triple-Negative Breast Tumor.

Published in:

Nanomaterials (2079-4991), 2025, v. 15, n. 13, p. 1006, doi. 10.3390/nano15131006

By:

Ji, Ying;
Li, Juan;
Ma, Li;
Wang, Zhijie;
Du, Bochu;
Kwan, Hiu Yee;
Bian, Zhaoxiang;
Chu, Chih-Chang

Publication type:

Article

Editorial: Community series in cell network in antitumor immunity of pediatric and adult solid tumors, volume II.

Published in:

2025

By:

Melaiu, Ombretta;
Bernson, Elin;
Pesce, Silvia

Publication type:

Editorial

A bibliometric analysis of immune escape in colorectal cancer: research trends, key contributors, and future directions.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1614613

By:

Zha, Bowen;
He, Jiahui;
Li, Chunguang

Publication type:

Article

TIPE regulates TGFB2 expression and induces extracellular M2 polarization in CRC Open Access.

Published in:

Journal of Leukocyte Biology, 2025, v. 117, n. 6, p. 1, doi. 10.1093/jleuko/qiaf066

By:

Zhu, Qiang;
Zhang, Shiying;
Yan, Changxiu;
Lin, Zeyang;
Zhang, Shuaishuai;
Li, Haoyang;
Ye, Yuhan;
Liu, Zhongchen;
Zhuang, Guohong;
Zhang, Kun

Publication type:

Article

Investigating the correlation between tertiary lymphoid structures and clinical outcomes in pancreatic ductal adenocarcinoma: insights into tumor immunology.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1569947

By:

Hu, Lingbo;
Xiao, Yanhong;
Jiang, Ning;
Hu, Yufen;
Qiu, Liewang;
Geng, Bo

Publication type:

Article

The human microbiota: a double-edged sword against the 'Sword of Damocles' in PDAC diagnosis and therapy.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1519277

By:

Sindaco, Maria;
Mercanti, Leonardo;
Puca, Valentina;
Mazzone, Mariangela;
Di Marcantonio, Maria Carmela;
Muraro, Raffaella;
Fiordaliso, Michele;
Mincione, Gabriella

Publication type:

Article

Senescence-associated signature based on immunotherapy response sequencing reveals PPIL3 as target for bladder cancer treatment and prognosis prediction.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1613056

By:

Du, Kaixuan;
Kang, Ning;
Lin, Yuda;
Jia, Kaipeng;
Shen, Chong;
Wu, Zhouliang;
Hu, Hailong

Publication type:

Article

Multi-omics analysis reveals the role of ribosome biogenesis in malignant clear cell renal cell carcinoma and the development of a machine learning-based prognostic model.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1602898

By:

Xie, Zhouzhou;
Peng, Shansen;
Wang, Jiongming;
Huang, Yueting;
Zhou, Xiaoqi;
Zhang, Guihao;
Jiang, Huiming;
Zhong, Kaihua;
Feng, Lingsong;
Chen, Nanhui

Publication type:

Article

The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1550651

By:

De Re, Valli;
Casarotto, Mariateresa;
Brisotto, Giulia;
Zanussi, Stefania;
De Zorzi, Mariangela;
Repetto, Ombretta;
Muraro, Elena;
Spessotto, Paola;
Baldo, Paolo;
Racanelli, Vito;
Lenti, Marco Vincenzo;
Venerito, Marino;
Fassan, Matteo;
Steffan, Agostino;
Realdon, Stefano;
Cannizzaro, Renato

Publication type:

Article

Rational therapeutic targeting of myeloid cells in glioblastoma: challenges and perspectives.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1472710

By:

Akay, Faruk;
Saleh, Maya

Publication type:

Article