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- Title
The elusive magic pill: finding effective therapies for mitochondrial disorders.
- Authors
Goldstein, Amy; Wolfe, Lynne A
- Abstract
The incidence of mitochondrial diseases has been estimated at 11.5/100,000 (1:8500) worldwide. In the USA up to 4000 newborns annually are expected to develop a mitochondrial disease. More than 50 million adults in the USA also suffer from diseases in which primary or secondary mitochondrial dysfunction is involved. Mitochondrial dysfunction has been identified in cancer, infertility, diabetes, heart diseases, blindness, deafness, kidney disease, liver disease, stroke, migraine, dwarfism, and resulting from numerous medication toxicities. Mitochondrial dysfunction is also involved in normal aging and age-related neurodegenerative diseases, such as Parkinson and Alzheimer diseases. Yet most treatments available are based on empiric data and clinician experience because of the lack of randomized controlled clinical trials to provide evidence-based treatments for these disorders. Here we explore the current state of research for the treatment of mitochondrial disorders.
- Publication
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2013, Vol 10, Issue 2, p320
- ISSN
1878-7479
- Publication type
Journal Article
- DOI
10.1007/s13311-012-0175-0