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- Title
Neutral Zone Classifiers Using a Decision-Theoretic Approach With Application to DNA Array Analyses.
- Authors
Yu, Hua; Jeske, Daniel R; Ruegger, Paul; Borneman, James
- Abstract
Two-class neutral zone classifiers were recently proposed for use in microbial community profiling applications. These classifiers allow a region of neutrality for cases where probe hybridization outcomes are too ambiguous to have adequate confidence in assigning a "binding" or "no binding" result. In this paper, we generalize the idea of neutral zone classifiers to an arbitrary number of classes and apply it to improve the process of microbial community profiling by considering a third class for the outcome of probe hybridization experiments, "partial binding." We introduce a family of class distributions that uses a mixture of Gaussian distributions as a model for a Box-Cox power transformation of the raw intensity measurements. Stratified cross-validation analyses are used to assess the efficacy of the proposed three-class neutral zone classifier. This article has supplementary material online.
- Publication
Journal of agricultural, biological, and environmental statistics, 2010, Vol 15, Issue 4, p474
- ISSN
1085-7117
- Publication type
Journal Article
- DOI
10.1007/s13253-010-0034-6