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- Title
Identification and characterization of anesthetic targets by mouse molecular genetics approaches.
- Authors
Drexler, Berthold; Antkowiak, Bernd; Engin, Elif; Rudolph, Uwe
- Abstract
It is now generally accepted that proteins are the primary targets of general anesthetics. However, the demonstration that the activity of a protein is altered by general anesthetics at clinically relevant concentrations in vitro does not provide direct evidence that this target mediates pharmacological actions of general anesthetics. Here we report on advances that have been made in identifying the contribution of individual ligand-gated ion channels to defined anesthetic endpoints using molecular mouse genetics.
- Publication
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2011, Vol 58, Issue 2, p178
- ISSN
1496-8975
- Publication type
Journal Article
- DOI
10.1007/s12630-010-9414-1