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- Title
Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides.
- Authors
Wurtman, R J; Cansev, M; Ulus, I H
- Abstract
The loss of cortical and hippocampal synapses is a universal hallmark of Alzheimer's disease, and probably underlies its effects on cognition. Synapses are formed from the interaction of neurites projecting from "presynaptic" neurons with dendritic spines projecting from "postsynaptic" neurons. Both of these structures are vulnerable to the toxic effects of nearby amyloid plaques, and their loss contributes to the decreased number of synapses that characterize the disease. A treatment that increased the formation of neurites and dendritic spines might reverse this loss, thereby increasing the number of synapses and slowing the decline in cognition.
- Publication
The journal of nutrition, health & aging, 2009, Vol 13, Issue 3, p189
- ISSN
1279-7707
- Publication type
Journal Article
- DOI
10.1007/s12603-009-0056-3