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- Title
Mifepristone treatment of olanzapine-induced weight gain in healthy men.
- Authors
Gross, Coleman; Blasey, Christine M; Roe, Robert L; Allen, Kate; Block, Thaddeus S; Belanoff, Joseph K
- Abstract
Antipsychotic medications are associated with significant weight gain, type 2 diabetes mellitus, dyslipidemia, and increased cardiovascular risk. Suggested mechanisms of weight gain from antipsychotic medication include antagonism of histamine and serotonin receptors, and effects on the hypothalamic-pituitary-adrenal axis. The objective of this study was to determine if mifepristone, a glucocorticoid receptor antagonist, could prevent olanzapine-induced weight gain.
- Publication
Advances in therapy, 2009, Vol 26, Issue 10, p959
- ISSN
1865-8652
- Publication type
Journal Article
- DOI
10.1007/s12325-009-0070-1