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- Title
Antidepressant-like effects and memory enhancement of a herbal formula in mice exposed to chronic mild stress.
- Authors
Sun, Xiu-Ping; Li, Si-Di; Shi, Zhe; Li, Teng-Fei; Pan, Rui-Le; Chang, Qi; Qin, Chuan; Liu, Xin-Min
- Abstract
Shen Yuan Gan (SYG) is a Chinese herbal prescription composed of total saponins of Panax ginseng and total oligosaccharide esters of Polygala tenuifolia (2:1). Our previous studies have demonstrated that SYG has antidepressant-like effects in various mouse models of behavioral depression. The present study aimed to test whether SYG affected chronic mild stress (CMS)-induced depression and cognitive impairment in mice. We found that a 5-week CMS schedule induced significant degradation of the coat state, decreased sucrose intake in the sucrose-preference test, and increased the latency to feed in the noveltysuppressed feeding test. All of these CMS-induced changes were ameliorated by SYG (100 and 200 mg/kg) and fluoxetine (10 mg/kg). In addition, SYG restored the decreased monoamine neurotransmitter concentrations (serotonin, dopamine, norepinephrine and acetylcholine) induced by CMS in the prefrontal cortex. Interestingly, SYG ameliorated CMS-induced cognitive impairment in the step-through test, and increased the acetylcholine level in the prefrontal cortex. These results suggest that SYG has an antidepressant-like action and enhances cognition by modulating the serotonin, dopamine, norepinephrine, and acetylcholine levels in the prefrontal cortex.
- Publication
Neuroscience bulletin, 2013, Vol 29, Issue 6, p737
- ISSN
1995-8218
- Publication type
Journal Article
- DOI
10.1007/s12264-013-1378-z