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- Title
The changing face of head and neck cancer in the 21st century: the impact of HPV on the epidemiology and pathology of oral cancer.
- Authors
Westra, William H
- Abstract
The longstanding notion that head and neck squamous cell carcinoma (HNSCC) is a uniform disease process is changing. Divergence in epidemiologic trends among HNSCCs arising in different anatomic subsites has introduced a view that HNSCC is a heterogeneous group. Analysis of molecular genetic changes discloses not just individual tumor differences, but also consistent large-scale differences that permit the recognition of important tumor subtypes. One recently recognized subtype is the human papillomavirus (HPV)-positive oropharyngeal carcinoma. HPV-positive oropharyngeal cancer now dominates the head and neck oncology landscape, and its escalating incidence is impacting on diagnostic, preventive and therapeutic practices.
- Publication
Head and neck pathology, 2009, Vol 3, Issue 1, p78
- ISSN
1936-0568
- Publication type
Journal Article
- DOI
10.1007/s12105-009-0100-y