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- Title
Function and dysfunction of α-synuclein: probing conformational changes and aggregation by single molecule fluorescence.
- Authors
Trexler, Adam J; Rhoades, Elizabeth
- Abstract
The aggregation and deposition of the neuronal protein α-synuclein in the substantia nigra region of the brain is a key pathological feature of Parkinson's disease. α-Synuclein assembles from a monomeric state in solution, which lacks stable secondary and tertiary contacts, into highly structured fibrillar aggregates through a pathway which involves the population of multiple oligomeric species over a range of time scales. These features make α-synuclein well suited for study with single-molecule techniques, which are particularly useful for characterizing dynamic, heterogeneous samples. Here, we review the current literature featuring single-molecule fluorescence studies of α-synuclein and discuss how these studies have contributed to our understanding of both its function and its role in disease.
- Publication
Molecular neurobiology, 2013, Vol 47, Issue 2, p622
- ISSN
1559-1182
- Publication type
Journal Article
- DOI
10.1007/s12035-012-8338-x