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- Title
Urinary bladder function and somatic sensitivity in vasoactive intestinal polypeptide (VIP)-/- mice.
- Authors
Studeny, Simon; Cheppudira, Bopaiah P; Meyers, Susan; Balestreire, Elena M; Apodaca, Gerard; Birder, Lori A; Braas, Karen M; Waschek, James A; May, Victor; Vizzard, Margaret A
- Abstract
Vasoactive intestinal polypeptide (VIP) is an immunomodulatory neuropeptide widely distributed in neural pathways that regulate micturition. VIP is also an endogenous anti-inflammatory agent that has been suggested for the development of therapies for inflammatory disorders. In the present study, we examined urinary bladder function and hindpaw and pelvic sensitivity in VIP(-/-) and littermate wildtype (WT) controls. We demonstrated increased bladder mass and fewer but larger urine spots on filter paper in VIP(-/-) mice. Using cystometry in conscious, unrestrained mice, VIP(-/-) mice exhibited increased void volumes and shorter intercontraction intervals with continuous intravesical infusion of saline. No differences in transepithelial resistance or water permeability were demonstrated between VIP(-/-) and WT mice; however, an increase in urea permeability was demonstrated in VIP(-/-) mice. With the induction of bladder inflammation by acute administration of cyclophosphamide, an exaggerated or prolonged bladder hyperreflexia and hindpaw and pelvic sensitivity were demonstrated in VIP(-/-) mice. The changes in bladder hyperreflexia and somatic sensitivity in VIP(-/-) mice may reflect increased expression of neurotrophins and/or proinflammatory cytokines in the urinary bladder. Thus, these changes may further regulate the neural control of micturition.
- Publication
Journal of molecular neuroscience : MN, 2008, Vol 36, Issue 1-3, p175
- ISSN
0895-8696
- Publication type
Journal Article
- DOI
10.1007/s12031-008-9100-8