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- Title
Impairment of flow-mediated vasodilatation of brachial artery in patients with Cushing’s Syndrome.
- Authors
Merih Baykan; Cihangir Erem; Ömer Gedikli; Arif Hacihasanoglu; Turan Erdogan; Mustafa Kocak; İsmet Durmuş; Levent Korkmaz; Şükrü Çelik
- Abstract
BackgroundCushing’s Syndrome (CS) is associated with excess and premature cardiovascular disease. Endothelial dysfunction is the initiating event in the development of atherosclerosis. Endothelial function is assessed by flow-mediated dilatation (FMD) of brachial artery. The aim of this study was to assess FMD in patients with CS.MethodsWe prospectively evaluated 22 patients with CS (12 women, 10 men; aged 42 ± 11 years, serum cortisol 28.2 ± 14 μg/dl, 24-h urinary free cortisol (UFC) 269 ± 92 μg/day), and 23 control subjects (13 women, 10 men; aged 43 ± 10 years, serum cortisol 14 ± 4 μg/dl, 24 h cortisol 60 ± 22 μg/day). Endothelial function, measured as FMD of the brachial artery using ultrasound, was calculated in two groups. Endothelial function was evaluated by assessing 1-min postischemic FMD of the brachial artery.ResultsFMD was lower in patients with CS than that in those without (11.7 ± 4.8% vs. 15.8 ± 3.2%, P = 0.0001, respectively). There was no significant difference between two groups regarding baseline diameter of brachial artery. But, hyperemia diameter was lower in patients with CS than without CS (3.6 ± 0.22 mm vs. 3.9 ± 0.19 mm, P = 0.04, respectively)ConclusionEndothelium-dependent FMD may impair in patients with CS compared to controls. Measurement of endothelial function may identify high-risk individuals early and therapy to reduce or retard endothelial dysfunction in patients with CS may lead to decreased cardiovascular morbidity and mortality.
- Publication
Endocrine (1355008X), 2007, Vol 31, Issue 3, p300
- ISSN
1355-008X
- Publication type
Academic Journal
- DOI
10.1007/s12020-007-0033-8