We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Curcumin inhibits the Sortase A activity of the Streptococcus mutans UA159.
- Authors
Hu, Ping; Huang, Ping; Chen, Wei Min
- Abstract
Streptococcus mutans (S. mutans) forms part of the commensal microflora and is deemed to be the major pathogen responsible for the generation of dental caries. The enzyme, sortase A enzyme, modulates the surface properties and cariogenicity of S. mutans. Curcumin has been reported to be an inhibitor of Staphylococcus aureus sortase A. In this study, inhibition of a purified S. mutans UA159 sortase A by curcumin was evaluated. Curcumin exerted strong inhibitory activity with a half maximal inhibitory concentration (IC50) of 10.2 ± 0.7 μM which was lower than the minimum inhibitory concentration of 175 μM and the minimum bactericidal concentration of 350 μM. These results indicated that curcumin is a S. mutans UA159 sortase A inhibitor and therefore represents as a promising anticaries agent.
- Publication
Applied biochemistry and biotechnology, 2013, Vol 171, Issue 2, p396
- ISSN
1559-0291
- Publication type
Journal Article
- DOI
10.1007/s12010-013-0378-9