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Title
Amphotericin B delivery from bone cement increases with porosity but strength decreases.
Authors
Kweon, Chris; McLaren, Alex C; Leon, Christine; McLemore, Ryan
Abstract
Amphotericin B is a highly hydrophobic antifungal used for orthopaedic infections. There is disagreement about whether amphotericin B is released when it is loaded in polymethylmethacrylate (PMMA). It is unknown how much a poragen will increase amphotericin B release or decrease the compressive strength of the PMMA.
Publication
Clinical orthopaedics and related research, 2011, Vol 469, Issue 11, p3002