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- Title
Impact of genetics on the diagnosis and treatment of renal cancer.
- Authors
Singer, Eric A; Bratslavsky, Gennady; Middelton, Lindsay; Srinivasan, Ramaprasad; Linehan, W Marston
- Abstract
Kidney cancer is a heterogeneous disease comprised of a number of histologic subtypes, each associated with unique genetic mutations, clinical features, and sensitivity to treatment. By examining families affected with the hereditary kidney cancer syndromes von Hippel-Lindau, hereditary papillary renal cell carcinoma, hereditary leiomyomatosis and renal cell carcinoma, and Birt-Hogg-Dubé, researchers have been able to identify the genes responsible for these syndromes. This work has revealed that kidney cancer is fundamentally a metabolic disorder, and as such, novel targeted therapies specific to their molecular biology have been developed and employed in both the hereditary and sporadic forms of renal cell carcinoma.
- Publication
Current urology reports, 2011, Vol 12, Issue 1, p47
- ISSN
1534-6285
- Publication type
Journal Article
- DOI
10.1007/s11934-010-0156-y