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- Title
Nitric oxide synthases and osteoarthritis.
- Authors
Scher, Jose U; Pillinger, Michael H; Abramson, Steven B
- Abstract
The production of nitric oxide (NO) by chondrocytes is increased in human osteoarthritis. The excessive production of NO inhibits matrix synthesis and promotes its degradation. Furthermore, by reacting with oxidants such as superoxide anion, NO promotes cellular injury and renders the chondrocyte susceptible to cytokine-induced apoptosis. Thus, NO produced by activated chondrocytes in diseased cartilage may modulate disease progression in osteoarthritis and should therefore be considered a potential target for therapeutic intervention.
- Publication
Current rheumatology reports, 2007, Vol 9, Issue 1, p9
- ISSN
1523-3774
- Publication type
Journal Article
- DOI
10.1007/s11926-007-0016-z