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- Title
Wegener's granulomatosis: is biologic therapy useful?
- Authors
Sarraf, Pasha; Kay, Jonathan; Friday, Robert P; Reginato, Anthony M
- Abstract
Wegener's granulomatosis (WG) is a complex autoimmune disorder that has been transformed from a uniformly lethal process to a chronic disease with a relapsing-remitting course. In the setting of frequent relapses, the need to manage cumulative disease damage and drug toxicities has spurred the identification and development of new potent and directed therapies. Biologic agents, which offer the potential for remission-induction and drug-sparing approaches to treat WG, have been studied in several small, open-label clinical series and one large, randomized, placebo-controlled clinical trial. This article discusses the results of these trials and the potential of these biologic agents to treat WG.
- Publication
Current rheumatology reports, 2006, Vol 8, Issue 4, p303
- ISSN
1523-3774
- Publication type
Journal Article
- DOI
10.1007/s11926-006-0014-6