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- Title
Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss.
- Authors
Zaidi, Mone; Turner, Charles H; Canalis, Ernesto; Pacifici, Roberto; Sun, Li; Iqbal, Jameel; Guo, X Edward; Silverman, Stuart; Epstein, Solomon; Rosen, Clifford J
- Abstract
Recent reports suggest that bone loss begins during late perimenopause at a dramatic rate, even before estrogen levels plummet. During the ensuing 5 years, there is evidence of the beginnings of microarchitectural deterioration, which impacts bone strength and ultimately enhances its propensity to fracture. The diagnosis of osteoporosis based on T-scores alone, or through stratification for a high fracture risk by FRAX, excludes these women who are rapidly losing bone. Because all antiosteoporosis therapies, in particular bisphosphonates, reduce bone loss, we propose aggressive, likely short-term therapy with a goal to reduce bone loss, stabilize bone density, and prevent microarchitectural deterioration.
- Publication
Current osteoporosis reports, 2009, Vol 7, Issue 4, p118
- ISSN
1544-2241
- Publication type
Journal Article
- DOI
10.1007/s11914-009-0021-4