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- Title
Drug development in advanced colorectal cancer: challenges and opportunities.
- Authors
Kelley, Robin; Venook, Alan P
- Abstract
Despite recent advances in treatment options, advanced colorectal cancer (ACC) remains a leading cause of cancer death worldwide, and new therapies are needed to improve the grim prognosis of this disease. Drug development in ACC faces the challenges of a constrained pipeline, a paucity of patients enrolled in clinical trials, and an outdated "one drug fits all" model of clinical research. This article discusses potential innovations in clinical trial design--including enrichment strategies, novel patient populations, and the use of randomization in the phase 2 setting--to optimize the testing of new therapies. It concludes with a selection of promising agents and pathways under investigation in ACC.
- Publication
Current oncology reports, 2009, Vol 11, Issue 3, p175
- ISSN
1534-6269
- Publication type
Journal Article
- DOI
10.1007/s11912-009-0026-2