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- Title
The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants.
- Authors
Bonner, Michael F; Ash, Sharon; Grossman, Murray
- Abstract
Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer's disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants of PPA are now recognized: semantic variant, logopenic variant, and nonfluent/agrammatic variant. We discuss recent work characterizing the neurolinguistic, neuropsychological, imaging and pathologic profiles associated with these variants. Improved reliability of diagnoses will be increasingly important as trials for etiology-specific treatments become available. We also discuss the implications of these syndromes for theories of language function.
- Publication
Current neurology and neuroscience reports, 2010, Vol 10, Issue 6, p484
- ISSN
1534-6293
- Publication type
Journal Article
- DOI
10.1007/s11910-010-0140-4