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- Title
Modulation of pressure-natriuresis by renal medullary reactive oxygen species and nitric oxide.
- Authors
O'Connor, Paul M; Cowley, Allen W, Jr
- Abstract
The renal pressure-natriuresis mechanism is the dominant controller of body fluid balance and long-term arterial pressure. In recent years, it has become clear that the balance of reactive oxygen and nitrogen species within the renal medullary region is a key determinant of the set point of the renal pressure-natriuresis curve. The development of renal medullary oxidative stress causes dysfunction of the pressure-natriuresis mechanism and contributes to the development of hypertension in numerous disease models. The purpose of this review is to point out the known mechanisms within the renal medulla through which reactive oxygen and nitrogen species modulate the pressure-natriuresis response and to update the reader on recent advances in this field.
- Publication
Current hypertension reports, 2010, Vol 12, Issue 2, p86
- ISSN
1534-3111
- Publication type
Journal Article
- DOI
10.1007/s11906-010-0094-6