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- Title
The evolution of renin-angiotensin blockade: angiotensin-converting enzyme inhibitors as the starting point.
- Authors
Sica, Domenic A
- Abstract
The renin-angiotensin system has been a target in the treatment of hypertension for close to three decades. Several medication classes that block specific aspects of this system have emerged as useful therapies, including angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and, most recently, direct renin inhibitors. There has been a natural history to the development of each of these three drug classes, starting with their use as antihypertensive agents; thereafter, in each case they have been employed as end-organ protective agents. To date, there has been scant evidence to favor angiotensin receptor blockers or direct renin inhibitors over angiotensin-converting enzyme inhibitors in treating hypertension or in affording end-organ protection; thus, angiotensin-converting enzyme inhibitors remain the standard of care when renin-angiotensin system blockade is warranted.
- Publication
Current hypertension reports, 2010, Vol 12, Issue 2, p67
- ISSN
1534-3111
- Publication type
Journal Article
- DOI
10.1007/s11906-010-0091-9