We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Insights into IBD Pathogenesis.
- Authors
Shih, David Q; Targan, Stephan R
- Abstract
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder caused by dysregulated immune responses in a genetically predisposed individual. Recent accumulating data, including genome-wide association studies, have identified more than 50 distinct genetic loci that confer susceptibility. We highlight the role of microbial-host interaction, particularly with respect to the overlap of common genetic and pathophysiologic mechanisms of CD and UC, interleukin-22-producing natural killer cells, autophagy, and TL1A, a member of the tumor necrosis factor (TNF) family, in gut homeostasis and IBD pathogenesis. This article focuses on the recent advances in understanding of IBD from the past year, including advances in genetics and immunobiology.
- Publication
Current gastroenterology reports, 2009, Vol 11, Issue 6, p473
- ISSN
1534-312X
- Publication type
Journal Article
- DOI
10.1007/s11894-009-0072-9