We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Early nephropathy in type 1 diabetes: a new perspective on who will and who will not progress.
- Authors
Perkins, Bruce A; Krolewski, Andrzej S
- Abstract
Impaired renal function and end-stage renal disease (ESRD) affect up to a third of patients with type 1 diabetes. Thus, strategies for early detection and for preventative interventions are of critical importance. A model of diabetic nephropathy was developed in the 1980s that placed paramount importance on the finding of microalbuminuria as an early marker of a committed process of progressive kidney disease in diabetes. However, recent studies have provided evidence that microalbuminuria is a marker of dynamic, rather than fixed, kidney injury. Preliminary studies into early renal function decline, a process measured in early nephropathy using a simple assay for cystatin C to calculate the slope of glomerular filtration rate change over time, suggest that it is a more proximal marker than microalbuminuria of a person's trajectory toward impaired renal function and ESRD. Therefore, early renal function decline, rather than microalbuminuria, may be considered as the early marker of the committed process underlying progressive diabetic nephropathy.
- Publication
Current diabetes reports, 2005, Vol 5, Issue 6, p455
- ISSN
1534-4827
- Publication type
Journal Article
- DOI
10.1007/s11892-005-0055-7