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- Title
Myeloperoxidase production by macrophage and risk of atherosclerosis.
- Authors
Karakas, Mahir; Koenig, Wolfgang
- Abstract
Myeloperoxidase (MPO), a member of the heme peroxidase superfamily, is a leukocyte-derived enzyme that generates reactive intermediates, leading to oxidative damage of host lipids and proteins. It has been shown that MPO is present within atherosclerotic plaque in human arteries and contributes to atherogenesis by catalyzing oxidative reactions in the vascular wall. This review provides an overview of the analytical and pathophysiologic characteristics of MPO and summarizes the possible clinical applicability of MPO as a marker for diagnosis of acute coronary syndrome and a marker for prediction of cardiovascular disease.
- Publication
Current atherosclerosis reports, 2012, Vol 14, Issue 3, p277
- ISSN
1534-6242
- Publication type
Journal Article
- DOI
10.1007/s11883-012-0242-3