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- Title
Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.
- Authors
Ober, Carole; Pan, Lin; Phillips, Natasha; Parry, Rodney; Kurina, Lianne M
- Abstract
Identifying genes that influence susceptibility to asthma-related and atopy-related phenotypes has been challenging, owing to clinical heterogeneity and a complex underlying genetic architecture that includes both gene-gene and gene-environment interactions. In this article, we report the results of genome-wide linkage and association studies of eight asthma-associated quantitative traits in the Hutterites, a founder population of European descent. Our study revealed significant sex-specific genetic architecture for at least five of these traits, and identified 13 genome-wide significant quantitative trait loci (QTL) by linkage or association that are present in only one of the sexes (nine in males, four in females).
- Publication
Current allergy and asthma reports, 2006, Vol 6, Issue 3, p241
- ISSN
1529-7322
- Publication type
Journal Article
- DOI
10.1007/s11882-006-0041-4