We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The role of the FOXP3 transcription factor in the immune regulation of allergic asthma.
- Authors
Schmidt-Weber, Carsten B; Blaser, Kurt
- Abstract
Unbalanced immune reactions against allergens are caused by Th2 cells, which are the basis of immunoglobulin E (IgE)-mediated symptoms of allergy and asthma. Although Th2 cells are essential for allergy, they are not sufficient to cause disease, because regulatory T cells (Tregs) control their activity and expansion. Therefore, Tregs are assumed to play an important role not only in the sensitization but also in established allergic disease under therapy. A key factor of Tregs is FOXP3, which, upon expression, is sufficient to induce regulatory T-cell phenotypes. The initiation and suppressive function of FOXP3 and Tregs in the context of allergic asthma are discussed in this review.
- Publication
Current allergy and asthma reports, 2005, Vol 5, Issue 5, p356
- ISSN
1529-7322
- Publication type
Journal Article
- DOI
10.1007/s11882-005-0006-z