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- Title
Alterations of central dopamine receptors before and after gastric bypass surgery.
- Authors
Steele, Kimberley E; Prokopowicz, Gregory P; Schweitzer, Michael A; Magunsuon, Thomas H; Lidor, Anne O; Kuwabawa, Hiroto; Kumar, Anil; Brasic, James; Wong, Dean F
- Abstract
While bariatric surgery has proved highly successful at producing sustained weight loss, variability in treatment response persists. A better understanding of the pathophysiology of appetite and obesity may improve patient selection and management. Research into feeding behavior and satiety has focused on the role of dopamine in reward-based behaviors. Specifically, positron-emission computed tomography (PET) has demonstrated reduced brain dopamine receptor availability in obese subjects compared to controls. This may be due to a primary deficiency in dopamine receptors or to secondary dopamine receptor downregulation. We performed a preliminary study to investigate dopamine D2 receptor activity in obese subjects before and after laparoscopic Roux-en Y gastric bypass (LGBP).
- Publication
Obesity surgery, 2010, Vol 20, Issue 3, p369
- ISSN
1708-0428
- Publication type
Journal Article
- DOI
10.1007/s11695-009-0015-4