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- Title
Genomic analysis of pterostilbene predicts its antiproliferative effects against pancreatic cancer in vitro and in vivo.
- Authors
McCormack, Denise Elizabeth; Mannal, Patrick; McDonald, Debbie; Tighe, Scott; Hanson, Joshua; McFadden, David
- Abstract
To investigate the inhibitory role of pterostilbene in pancreatic cancer, we conducted a genomic analysis of pterostilbene-treated pancreatic cancer cells. We also investigated the effect of pterostilbene upon the carcinogenic markers, manganese superoxide dismutase, cytochrome C, Smac/DIABLO, and STAT3 phosphorylation in vitro. The antiproliferative effects of pterostilbene were further evaluated in an in vivo model.
- Publication
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2012, Vol 16, Issue 6, p1136
- ISSN
1873-4626
- Publication type
Journal Article
- DOI
10.1007/s11605-012-1869-7