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- Title
Targeting insulin-like growth factor type 1 receptor in cancer therapy.
- Authors
Atzori, Francesco; Traina, Tiffany A; Ionta, Maria Teresa; Massidda, Bruno
- Abstract
It is believed that the insulin-like growth factor receptor type 1 (IGF-1R) signaling pathway plays a pivotal role in cancer growth, progression, and resistance to anticancer therapies. Strategies are being developed to block IGF-1R as an anticancer treatment. We reviewed several potential strategies for disrupting the IGF axis. We also reviewed the effects of two drugs that target the IGF-1R: monoclonal antibodies and tyrosine kinase inhibitors. Preliminary results of studies involving these agents provided a foundation for ongoing clinical trials, whose results in the near future will help us understand how to incorporate anti IGF-1R strategies into the current anticancer armamentarium.
- Publication
Targeted oncology, 2009, Vol 4, Issue 4, p255
- ISSN
1776-260X
- Publication type
Journal Article
- DOI
10.1007/s11523-009-0123-z